The Brewers will send Manny Parra (1-2) to the mound against Pittsburgh's Paul Maholm (2-4).
Pittsburgh has played well at home, going 12-8 so far this season. The Brewers have dropped nine-straight road games.
Milwaukee is in last place in the NL Central, trailing fourth place Pittsburgh and Cincinnati by 1-game. The Brewers are 7 1/2 games behind the division leading Chicago Cubs.