The Golden Eagles ran their conference win streak to nine games, tying the Big East record for consecutive wins.
Marquette (18-3, 9-0 Big East) led 36-31 at the half, then created some separation in the third quarter. They put together a 30-point quarter and led by as many as 32 points.
The Golden Eagles shot 49% from the field (26-53) and 48% from beyond the arc (11-23).
Butler was led by Kristen Spoylar with 21 points.
Marquette is off until Sunday when they take on DePaul in a 1 p.m. CT tip in Chicago.
Kelly Karlis hit a three-pointer from the corner as time expired to lift the Wisconsin Badgers (11-10, 2-7 Big Ten) to a 70-69 come-from-behind victory over the Nebraska Cornhuskers.
The win put an end to the Badgers six-game losing streak.
The Badgers also got 18 points from senior Marsha Howard and 17 from freshman Imani Lewis.