The Louisville Cardinals got 20 points from Terrence Williams and 17 points and 10 rebounds from David Padgett to help Louisville knock off 13th ranked Marquette 71-51 in Louisville, Kentucky.
Jerel McNeal led the Golden Eagles with 16 points and Wesley Matthews had 14, but Marquette shot just 30 percent from the field.
Dominic James scored a season-low three points before leaving with just over six minutes left with a wrist injury.
Marquette plays next at Connecticutt on Sunday.